MUTYH (MutY Homolog, MYH, A/G-specific adenine DNA glycosylase)

Human

Rabbit

Recombinant protein corresponding to Gly351-Ala544 of human MUTYH, expressed in E. coli.

Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.

MUTYH glycosylase, involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in the MUTYH gene cause an autosomal recessive form of familial adenomatous polyposis. Polyps caused by mutated MYH do not appear until adulthood and are less numerous than those found in patients with APC gene mutations.

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.

E IC IHC WB

Western Blot: 1:50-400 Immunocytochemistry: 1:50-500 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 ELISA: 1:100-1:5000 Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Recognizes human MUTYH.

Q9UIF7

Q9UIF7