MYO7A Recombinant Rabbit mAb (S-2284-21)

MYO7A, encoded by the MYO7A gene, is an unconventional, actin-based molecular motor protein expressed in the inner ear and retina, where it is essential for the development and maintenance of stereocilia in cochlear and vestibular hair cells (critical for mechanotransduction and balance) and for melanosome transport within retinal pigment epithelium (RPE) cells (supporting retinal function). This large protein comprises an N-terminal motor domain, a lever arm with IQ motifs, and a C-terminal tail with MyTH4-FERM domains and an SH3 domain, enabling cargo binding and dimerization to generate processive movement along actin tracks. Mutations in MYO7A cause Usher syndrome type 1B (USH1B), leading to congenital deafness, vestibular dysfunction, and progressive retinitis pigmentosa, as well as nonsyndromic hearing loss (DFNA11 and DFNB2).