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产品介绍
产品信息
商品描述
N-Arachidonoyl-serotonin is a selective FAAH (fatty acid amid hydrolase) and VR1 (transient receptor potential vanilloid-1, TRPV1) channel inhibitor. TRPV1 is a Capsaicin receptor, which behaves as a non-selective cation channel and are mainly found in the sensory neurons that detect painful stimuli. The compound has been shown to be inactive against cPLA2 and CB1. Rat brain studies suggests that N-Arachidonoyl-serotonin acts as an enhancer of endocannabinoid levels, and increases the levels of anadamide and 2-AG .
分子量
462.7
纯度
98%
可溶性
Soluble in DMSO (>25 mg/mL), ethanol (15 mg/mL), DMF (30 mg/mL), and PBS (pH 7.2) (~290 µg/mL).
外观
Oil
IC50
fatty acid amide hydrolase (FAAH): IC50 = 5.6 mM; TRPV1: IC50 = 40 nM
应用
实验应用
A selective FAAH and TRPV1 channel inhibitor
背景
分子式
C30H42N2O2
CAS号
187947-37-1
沸点
680.49° C at 760 mmHg (Predicted)
MDL
MFCD02179189
PK值
pKa: 10.08 (Predicted)
密度
1.04 g/mL (Predicted)
折射率
n20D 1.57 (Predicted)
制备和贮存
保存方式
Store at -20° C
参考图片
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