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N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
分子量
308.19
纯度
95%
可溶性
Acetonitrile, Dichloromethane, Methanol
外观
White Solid
In vitro(体外研究)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
背景
分子式
C9H11BrN2O5
CAS号
57159-62-3
制备和贮存
保存方式
-20℃，2 years
参考图片
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