Naked2 (C67C4) Rabbit mAb

Naked1 (Nkd1) and Naked2 (Nkd2) are homologs of Drosophila Naked cuticle, a negative regulator of Wnt/Wingless signaling pathway which functions through a feedback mechanism (1,2). Both Drosophila and vertebrate Naked proteins contain a putative calcium-binding EF-hand motif, however, Drosophila Naked binds to zinc instead of calcium (3). Naked inhibits the canonical Wnt/β-catenin pathway by binding to Dishevelled proteins and directs Dishevelled activity towards the planar cell polarity pathway (2,4). Naked1 is a direct target of Wnt signaling and is overexpressed in some colon tumors due to constitutive activation of Wnt/β-catenin pathway (5). Naked2 is myristoylated and is required for sorting of TGF-α to the basolateral plasma membrane of polarized epithelial cells (6). 1.Zeng, W. et al. (2000) Nature 403, 789-795. 2.Wharton, K.A. et al. (2001) Dev. Biol. 234, 93-106. 3.Rousset, R. et al. (2002) J. Biol. Chem. 277, 49019-49026. 4.Yan, D. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 3802-3807. 5.Yan, D. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 14973-14978. 6.Li, C. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 5571-5576.