NaPi2b/SLC34A2 (D6W2G) Rabbit mAb

The sodium-dependent phosphate transport protein 2B (NaPi-2b, SLC34A2) is a sodium dependent inorganic phosphate (Pi) transporter that regulates phosphate homeostasis in various organs, including the small intestine, lung, liver, and testis (1). In the small intestine, NaPi-2b localizes to the intestinal brush border membrane to mediate Pi reabsorption (2). In the lung, NaPi-2b is expressed in the apical membrane of type II alveolar cells and is involved in the synthesis of surfactant (3). Mutations in the corresponding SLC34A2 gene causes pulmonary alveolar microlithiasis, a rare autosomal recessive disorder characterized by the deposition of calcium phosphate microliths throughout the lungs (4). Research studies show aberrant expression of NaPi-2b in various type of cancer, including ovarian, breast, and lung cancer (5). Chromosomal rearrangements involving SLC34A2-ROS1 are seen in gastric carcinoma and non-small cell lung cancer and result in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity (6,7). 1.Xu, H. et al. (1999) Genomics 62, 281-4. 2.Hilfiker, H. et al. (1998) Proc Natl Acad Sci U S A 95, 14564-9. 3.Traebert, M. et al. (1999) Am J Physiol 277, L868-73. 4.Yin, X. et al. (2013) Respir Med 107, 217-22. 5.Kiyamova, R. et al. (2011) Exp Oncol 33, 157-61. 6.Davies, K.D. et al. (2012) Clin Cancer Res 18, 4570-9. 7.Lee, J. et al. (2013) Cancer 119, 1627-35.