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Natamycin
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产品介绍
产品介绍
产品信息
商品描述
Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research.
分子量
665.73
纯度
98%
可溶性
DMSO ：7 mg/mL (10.51 mM)
外观
White to light yellow powder
In vitro(体外研究)
Natamycin binds specifically to ergosterol present in model membranes. Natamycin does not change the permeability of the yeast plasma membrane under conditions that growth is blocked. Natamycin blocks the fusion of isolated vacuoles without compromising the barrier function of the vacuolar membrane. Natamycin perturbs the cellular vacuole morphology, causing the formation of many more small vacuolar structures in yeast cells. Natamycin inhibits the priming stage of vacuole fusion. Natamycin shows low MIC against the dematiaceous fungi, Curvularia species. Natamycin is complexed with gamma-cyclodextrin (NT-gamma CyD) to increase the solubility and stability of NT in aqueous solutions and reduce the side effects of the drug without decreasing antimycotic activity. MIC90 of Natamycin alone and Natamycin-gamma CyD complexes are below 0.0313 mg/mL, suggesting that complexation with gamma CyD has effectively increased the antimycotic activity of Natamycin, thus indicating the clinical usefulness of Natamycin-gamma CyD complexes.
背景
别名
纳他霉素；Pimaricin
分子式
C33H47NO13
CAS号
7681-93-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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