NAV 26 (10 mg)

44540282

Selective Na_v1.7 channel blocker

434.41

2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide

Selective Na_v1.7 channel blocker (IC₅₀ = 370 nM). Exhibits >85-fold selectivity for Na_v1.7 over Na_v1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 50 mM in ethanol

O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3

C₂₂H₂₁F₃N₂O₄

1198160-14-3