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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro597 of human NBR1 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
| Immunofluorescence (Immunocytochemistry) | 1:100 - 1:400 |
同种型
Rabbit IgG
分子量
140
应用
目标/特异性
Specificity/Sensitivity
NBR1 (E6Q3F) Rabbit mAb recognizes endogenous levels of total NBR1 protein. This antibody is suitable for detecting NBR1 by immunofluorescence when it's expressed at moderate-to-high levels.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Next to BRCA1 gene 1 (NBR1) protein is known for its encoding gene proximity to the BRCA1 tumor suppressor gene (1,2). N-terminal Phox and Bem1p (PB1) domains of NBR1 mediate its interaction with muscle specific titin kinase (3,4) and scaffolding protein p62 (4). NBR1 plays a role in selective autophagy by facilitating the autophagosomal degradation of ubiquitinated proteins independently and also in concert with p62 (5-11).
1.Campbell, I.G. et al. (1994) Hum Mol Genet 3, 589-94.
2.Miki, Y. et al. (1994) Science 266, 66-71.
3.Lange, S. et al. (2005) Science 308, 1599-603.
4.Müller, S. et al. (2006) FEBS Lett 580, 341-4.
5.Kirkin, V. et al. (2009) Mol Cell 33, 505-16.
6.Lamark, T. et al. (2009) Cell Cycle 8, 1986-90.
7.Kenific, C.M. and Debnath, J. (2016) Autophagy 12, 1958-1959.
8.Hafrén, A. and Hofius, D. (2017) Autophagy 13, 2000-2001.
9.Werner, A. et al. (2019) Autophagy 15, 78-97.
10.Sánchez-Martín, P. et al. (2020) EMBO Rep 21, e48902.
11.Turco, E. et al. (2021) Nat Commun 12, 5212.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
4077
UniProt ID
Q14596
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