Mouse Monoclonal NCAM-1/CD56 Antibody (SPM489)

Protein A or G purified

Mouse

Membrane preparation of a small cell lung carcinoma

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-34412) Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

0.2 mg/ml

0.05% Sodium Azide

Monoclonal

NCAM1

Flow Cytometry 0.5-1 ug/million cellsImmunocytochemistry/ Immunofluorescence 1-2 ug/mlImmunohistochemistry 0.5-1 ug/mlImmunohistochemistry-Paraffin 0.5-1ug/ml

HuSpecies Glossary

This monoclonal antibody reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.