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NCGC 607
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产品介绍
产品介绍
产品信息
商品描述
NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
分子量
543.36
纯度
98%
可溶性
DMSO:55 mg/mL (101.22 mM)
In vitro(体外研究)
NCGC607, a small-molecule noninhibitory chaperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry structure optimization.?This compound successfully chaperoned the mutant enzyme, restored glucocerebrosidase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronopathic Gaucher disease.?In addition, NCGC607 reduced α-synuclein levels in dopaminergic neurons from the patients with parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.
背景
分子式
C24H22IN3O4
CAS号
1462267-07-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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