NCX1 (D3F3H) Rabbit mAb

NCX1 (Na+/Ca2+ exchanger, isoform 1) belongs to a conserved family of sodium-calcium membrane antiporter proteins that play a fundamental role in regulating intracellular calcium levels (1). NCX1 facilitates transmembrane transport of Ca2+ ions in exchange for Na+ ions in response to electrochemical gradients (2). Due to its relatively low affinity for calcium, NCX1 most commonly functions to export Ca2+ under acute conditions of high intracellular Ca2+. Notably however, NCX1 is a reversible antiporter, and can thus facilate Ca2+ influx under specialized physiological circumstances (3). Research studies have shown that NCX1 is particularly important for regulating intracellular Ca2+ levels in excitatory cell types (e.g., neurons, cardiac muscle). For example, conditional knockout of NCX1 in mouse cardiac pacemaker cells identified a critical role for NCX1 in the initiation and maintenance of cardiac rhythm (4). 1.Sharma, V. and O'Halloran, D.M. (2014) Genesis 52, 93-109. 2.Yu, S.P. and Choi, D.W. (1997) Eur J Neurosci 9, 1273-81. 3.Lytton, J. (2007) Biochem J 406, 365-82. 4.Herrmann, S. et al. (2013) Cardiovasc Res 99, 780-8.