NCX1 (SLC8A1) ANTIBODY

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NCX1 (SLC8A1) ANTIBODY

品牌： Thermo

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产品介绍

产品信息

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫组化（石蜡） (IHC (P))

1:100

产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)EVDERDQDDEEAR, corresponding to amino acid residues 308-320 of rat NCX1, 3rd intracellular loop

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na-Ca exchanger; Na/Ca exchanger; Sodium/calcium exchanger 1; sodium/calcium exchanger isoform NaCa7; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8, member 1

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基因别名: AI852629; AV344025; CNC; D930008O12Rik; Ncx; NCX1; SLC8A1

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UniProt ID:(Human) P32418, (Mouse) P70414, (Rat) Q01728

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Entrez Gene ID:(Human) 6546, (Mouse) 20541, (Rat) 29715

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功能

calcium:sodium antiporter activity calcium ion binding protein binding calmodulin binding cytoskeletal protein binding ankyrin binding ion channel binding antiporter activity metal ion binding calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential secondary carrier transporter

参与通路

regulation of the force of heart contraction regulation of heart rate regulation of sodium ion transport ion transport cellular sodium ion homeostasis muscle contraction response to nutrient response to glucose regulation of cell communication by electrical coupling positive regulation of fibroblast migration regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling vascular smooth muscle contraction telencephalon development positive regulation of bone mineralization response to ATP cellular response to reactive oxygen species sodium ion transmembrane transport response to immobilization stress response to muscle stretch response to drug response to hydrogen peroxide relaxation of smooth muscle negative regulation of cytosolic calcium ion concentration cardiac muscle cell development calcium ion homeostasis relaxation of cardiac muscle cardiac muscle contraction cytosolic calcium ion transport calcium ion transport into cytosol calcium ion import calcium ion transmembrane transport cellular response to caffeine cellular response to cAMP sodium ion export cellular response to hypoxia membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction sodium ion import positive regulation of the force of heart contraction calcium ion export regulation of cardiac conduction response to hypoxia embryonic placenta development heart morphogenesis transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell communication positive regulation of cytosolic calcium ion concentration post-embryonic development embryonic heart tube development muscle fiber development regulation of calcium ion transport transmembrane transport regulation of cardiac muscle cell membrane potential

参考图片

Expression of NCX1 in rat heart - Immunohistochemical staining of rat heart paraffin-embedded sections using Anti-NCX1 (SLC8A1) Antibody (#ANX-011), (1:100). Hematoxilin is used as the counterstain. NCX1 labeling (brown) appears in the cardiac muscle cells (CM), and not in other parts of the tissue, such as the blood vessel endothelium (E), the connective tissue (CT) and smooth muscle (SM).

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: - 1,2. Anti-NCX1 (SLC8A1) Antibody (#ANX-011), (1:200).3,4. Anti-NCX1 (SLC8A1) Antibody , preincubated with NCX1/SLC8A1 Blocking Peptide (#BLP-NX011).

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) heart lysates: - 1,2. Anti-NCX1 (SLC8A1) Antibody (#ANX-011), (1:200).3,4. Anti-NCX1 (SLC8A1) Antibody , preincubated with NCX1/SLC8A1 Blocking Peptide (#BLP-NX011).

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货号：

ANX-011-200UL

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询价

200UL

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