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NEDD4L (E3 Ubiquitin-Protein Ligase NEDD4-Like, HECT-Type E3 Ubiquitin Transferase NED4L, NEDD4.2, Nedd4-2, KIAA0439, NEDL3)
NEDD4L (E3 Ubiquitin-Protein Ligase NEDD4-Like, HECT-Type E3 Ubiquitin Transferase NED4L, NEDD4.2, Nedd4-2, KIAA0439, NEDL3)
品牌： Usbiological
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对比
咨询纯度：
Purified by immunoaffinity chromatography.
反应种属：
Rabbit
产品介绍
产品介绍
产品信息
抗原来源
Human
宿主
Rabbit
免疫原
Recombinant protein corresponding to human NEDD4L, (Position: N703-D975), expressed in E. coli.
产品用途
Suitable for use in ELISA, Western Blot. Other applications not tested.
简单描述
Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 (NEDD4-2) is an enzyme (ubiquitin ligase) of the NEDD4 family. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
同种型
IgG
克隆类别
Polyclonal
纯度
Purified by immunoaffinity chromatography.
形式
Supplied as a lyophilized powder from PBS, 0.05% sodium azide, 4% trehalose. Reconstitute with 200ul sterile ddH2O.
应用
实验应用
E WB
推荐用量
ELISA: 0.1-0.5ug/ml Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher.
反应种属
Rabbit
交叉反应性
Hu Mo Rt
目标/特异性
Recognizes human NEDD4L. Species Crossreactivity: mouse, rat.
稀释度
ELISA: 0.1-0.5ug/ml Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher.
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
数据库链接
UniProt ID
Q96PU5
SwissProt
Q96PU5
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