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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
NeuN
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NeuN protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:250 - 1:1000 |
同种型
Rabbit IgG
分子量
46-55
研究领域
神经科学
应用
反应种属
Human,Mouse,Rat,
目标/特异性
Specificity/Sensitivity
NeuN (D3S3I) Rabbit mAb recognizes endogenous levels of total NeuN protein. A 30 kDa protein of unknown origin may be detected.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a nuclear protein expressed in most post-mitotic neurons of the central and peripheral nervous systems. NeuN is not detected in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius cells, INL retinal cells, inferior olivary, or dentate nucleus neurons (1). This neuronal protein was originally identified by immunoreactivity with a monoclonal antibody also called NeuN. Using MS analysis, NeuN was later identified as the Fox-3 gene product. Fox-3 contains an RNA recognition motif and functions as a splicing regulator (2). Fox-3 regulates alternative splicing of NumB, promoting neuronal differentiation during development (3).
1.Mullen, R.J. et al. (1992) Development 116, 201-11.
2.Kim, K.K. et al. (2009) J Biol Chem 284, 31052-61.
3.Kim, K.K. et al. (2013) J Cell Biol 200, 443-58.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
146713
UniProt ID
A6NFN3
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