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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NFS1 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
45
应用
目标/特异性
Specificity/Sensitivity
NFS1 (F1E7S) Rabbit mAb recognizes endogenous levels of total NFS1 protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Cysteine desulfurase (NFS1) is a component of the core complex of the de novo iron-sulfur cluster (ISC) assembly machinery in the mitochondrial matrix (1). This enzyme desulfurates L-cysteine. The sulfur from cysteine is used for the biosynthesis of ISCs (2,3). Studies show that high levels of NFS1 are essential to cancer cells when oxygen levels are above the 3–8% oxygen concentration typical of most tissues. Strong NFS1 expression is necessary for primary lung tumor growth and NFS1 protects lung adenocarcinomas from ferroptosis in reaction to oxidative damage (2). In addition, suppression of NFS1 expression leads to growth inhibition of some breast cancer cells (3).
1.Fox, N.G. et al. (2019) Nat Commun 10, 2210.
2.Alvarez, S.W. et al. (2017) Nature 551, 639-643.
3.Sviderskiy, V.O. et al. (2020) Mol Cell 80, 682-698.e7.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
9054
UniProt ID
Q9Y697
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