NIPP1 (Nuclear Inhibitor of Protein Phosphatase 1, NIPP-1, Protein Phosphatase 1 Regulatory Inhibitor Subunit 8, ARD1, PPP1R8)

Affinity Purified Purified by immunoaffinity chromatography.

nuclear inhibitor of protein phosphatase 1 isoform beta/delta

Synthetic peptide corresponding to C-EAWPGKKPTPSLLI, from human PPP1R8, at C-terminal (NP_002704.1, NP_054829.2, NP_612568.1).

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Polyclonal

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Bovine, Canine, Human, Mouse, Rat

Anti -NIPP1 (Nuclear Inhibitor of Protein Phosphatase 1, NIPP-1, Protein Phosphatase 1 Regulatory Inhibitor Subunit 8, ARD1, PPP1R8)

5511

Q12972 [Other Products]