Nkx-6.1 (5B8)

mouse

抗-Nkx-6.1 抗体 5B8 是小鼠单克隆 IgG2a κ，Nkx-6.1抗体, 在1篇文献中引用，规格为100 µg/mlraised against a full length recombinant protein Nkx-6.1 of human origin推荐用于 mouse, rat 和 human 来源的Nkx-6.1 WB 和 IP检测目前，我们还没有完成Nkx-6.1 抗体 (5B8)的首选二抗检测试剂的鉴定。这项工作正在进行中。 查看产品引用文献(1) Nkx-6.1 Antibody (5B8) is a high quality monoclonal Nkx-6.1 antibody (also designated NKX6-1 antibody, NKX6A antibody or Homeobox protein NK-6 homolog A antibody) suitable for the detection of the Nkx-6.1 protein of mouse, rat and human origin. Nkx-6.1 Antibody (5B8) is available as the non-conjugated anti-Nkx-6.1 antibody. Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature b cells, which produce insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic b cell specific genes, including insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in b cells.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Replacement monoclonal antibody for: sc-15027, sc-15030.

IGG-免疫球蛋白G型抗体

HumanNKX6-1