NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein)

Affinity Purified Purified by Protein G affinity chromatography.

NACHT, LRR and PYD domains-containing protein 3 isoform e

Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3 / NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckly-Wells sydrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Cryo-1

Supplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.

Monoclonal

Western Blot (WB)

Anti -NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein)

114548

Q96P20 [Other Products]