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NNC 711
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产品介绍
产品介绍
产品信息
商品描述
NNC 711 is a potent and selective inhibitor of GABA uptake by GABA T-1( (IC50 values are 0.04, 171, 1700 and 622 μM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chloride-dependent members that mediate the rapid removal of GABA. NNC 711 also exhibits cognition-enhancing activity.
分子量
386.88
纯度
≥99%
可溶性
Soluble in water (≥10 mg/mL) at 60° C, ethanol (10 mM), and DMSO (100 mM).
IC50
HGAT-1: IC50 = 0.04 µM ; RGAT-2: IC50 = 171 µM ; HGAT-3 : IC50 = 1700 µM ; HBGT-1: IC50 = 622 µM
Ki 数据
GABA transporter 1: Ki= 47 nM (Rattus norvegicus)
应用
实验应用
A potent and selective inhibitor of GABA T-1
背景
别名
NO-711 hydrochloride; 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy] ethyl]-3-pyridinecarboxylic acid hydrochloride
分子式
C21H22N2O3•HCl
CAS号
145645-62-1
沸点
541.2° C at 760 mmHg (Predicted)
MDL
MFCD00153853
PK值
pKa: 3.56 (Predicted), pKb: 7.76 (Predicted)
制备和贮存
保存方式
Desiccate at 4° C
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