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产品介绍
产品介绍
产品信息
荧光素标记
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu278 of human NRF1 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
同种型
Rabbit IgG
分子量
68
应用
目标/特异性
Specificity/Sensitivity
NRF1 (D9K7R) Rabbit mAb recognizes endogenous levels of total NRF1 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
敏感性
Endogenous
背景
背景
Nuclear respiratory factor 1 (NRF1) was identified as a transcription activator for the gene encoding cytochrome c (1). It was later found to play a role in the nuclear control of mitochondrial function (1). PGC-1 induces the expression of NRF1 and NRF2 (2). NRF1, along with the coactivator PGC-1, stimulates the promoter of mitochondrial transcription factor A, which regulates mitochondrial biogenensis and function (2).
1.Virbasius, C.A. et al. (1993) Genes Dev 7, 2431-45.
2.Wu, Z. et al. (1999) Cell 98, 115-24.
研究领域
癌症,代谢,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
4899
UniProt ID
Q16656
参考图片
Immunoprecipitation of NRF1 from HepG2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is NRF1 (D9K7R) Rabbit mAb. Western blot analysis was performed using NRF1 (D9K7R) Rabbit mAb.
Western blot analysis of extracts from HeLa, HepG2 and PC3 cell lysates using NRF1 (D9K7R) Rabbit mAb.
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