PDC-E2 (A-9)

mouse

PDC-E2抗体(A-9)是小鼠单克隆IgG1 (kappa轻链)，规格为200 µg/ml 特异性抗原位于human物种的PDC-E2的内部区域内的氨基酸83-117之间 推荐用于 mouse, rat， human 和 avian 来源的PDC-E2 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应，包括： 和 canine, porcine and avian m-IgG Fc BP-HRP and m-IgG1 BP-HRP 是 PDC-E2 Antibody (A-9) for WB and IHC(P)首选应用二抗。这些试剂现在以套装形式提供PDC-E2 Antibody (A-9) (见下方订购信息). Primary biliary cirrhosis (PBC) is a chronic, destructive autoimmune liver disease characterized by the presence of antimitochondrial autoantibodies in patient′s serum and T cell-mediated destruction of the biliary epithelial cells lining the small intrahepatic bile ducts. Patient sera are characterized by a high frequency (greater than 95%) of autoantibodies directed to a mitochondrial antigen, identified as the E2 component of the pyruvate dehydrogenase multienzyme complex (PDC-E2). PDC-E2 contains both an amino-terminal lipoyl-bearing domain and a carboxy-terminal catalytic domain. The human sequence preserves the Glu-Thr-Asp-Lys-Ala motif of the lipoyl-bearing site. Two conformationally alternative forms of the PDC-E2 protein have been revealed by immunoblotting. The immunodominant autoepitopes of the autoantigens correspond to the inner lipoyl domain. A significant number of asymptomatic patients found to have antibodies to PDC-E2 are at high risk of developing primary biliary cirrhosis.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

HumanDLAT

m, r, h

1737;235339