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产品介绍
产品介绍
产品信息
抗原名称
BTK
商品描述
ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral <b>BTK</b> inhibitor with <b>IC50</b> of 23.9 nM. Phase 1.
分子量
456.50
纯度
＞98%
可溶性
体外:
DMSO 20mg/mLwarming(43.81mM)
Water <1mg/mL
Ethanol <1mg/mLwarming
DMSO 20mg/mLwarming(43.81mM)
Water <1mg/mL
Ethanol <1mg/mLwarming
In vitro(体外研究)
In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.
背景
分子式
C25H24N6O3
CAS号
1351635-67-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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