OPN4

Recombinant fusion protein containing a sequence corresponding to aa365-489 of human OPN4 (NP_001025186.1).

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

IgG

Polyclonal

Purified by affinity chromatography.

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Western Blot: 1:500-1:2000 Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher.

Rabbit

Hu Mo Rt

Recognizes human OPN4. Species Crossreactivity: mouse and rat

OPN4; MOP; opsin 4

Q9UHM6