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Paired Immunoglobulin-Like Type 2 Receptor alpha (PILRa, PILR alpha)
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产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by immunoaffinity chromatography.
抗原名称
paired immunoglobulin-like type 2 receptor alpha
免疫原
Recombinant corresponding to aa20-196 from human PILR-a expressed in NSO cells (Q9UKJ1).
商品描述
PILR-a (paired immunoglobulin-like, type 2 receptor alpha) is a 44-50kD type I transmembrane (TM) paired receptor glycoprotein that belongs to the Ig Superfamily. It is expressed by monocytes, macrophages, CD14+CD1a- DC and retinal pigment cells, and is known to bind to CD99 and PANP. PILR-a acts as a receptor for HSV and serves as a negative immunomodulator that contains an ITIM. Mature human PILR-a is 284aa in length. It contains one V-type Ig-like domain in its extracellular region (aa32-150), and two ITIMs in its cytoplasmic domain (aa267-272 and 296-301). There are multiple potential splice variants. One is TM and possesses a 35 aa substitution for aa264-303, while others are soluble, and show a deletion of aa152-224 that may be coupled to the 35aa substitution noted above, or simply exhibit a 24aa substitution for aa152-303. Over aa20-196, human PILR-a shares only 42aa identity with mouse PILR-a, and 89aa identity with human PILR-b.
形式
Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
产品类型
Polyclonal
应用
实验应用
Flow Cytometry (FC/FACS)
反应种属
Human
背景
别名
Anti -Paired Immunoglobulin-Like Type 2 Receptor alpha (PILRa, PILR alpha)
制备和贮存
保存方式
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
数据库链接
NCBI
231805
UniProt ID
Q2YFS3
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