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PAN ASIC (EXTRACELLULAR) ANTIB
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Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acid sensing (proton gated) ion channel 1; acid sensing (proton gated) ion channel 2; acid sensing (proton gated) ion channel 3; acid sensing (proton gated) ion channel family member 4; acid sensing ion channel; acid sensing ion channel 1; acid sensing ion channel 2; acid sensing ion channel 3; acid sensing ion channel family member 4; acid-sensing (proton-gated) ion channel 1; acid-sensing (proton-gated) ion channel 2; acid-sensing (proton-gated) ion channel 3; acid-sensing (proton-gated) ion channel family member 4; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; Acid-sensing ion channel 2; Acid-sensing ion channel 3; Acid-sensing ion channel 4; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel 2, neuronal; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4, pituitary; amiloride-sensitive cation channel family member 4, pituitary; Amiloride-sensitive cation channel neuronal 1; ASIC1; ASIC2; ASIC3; ASIC4; BNaC2; BNC1; Brain sodium channel 1; Brain sodium channel 2; brain sodium channel 4; Cation channel, amiloride-sensitive, neuronal, 2; degenerin; degenerin 2; Dorsal root ASIC; DRASIC; hTNaC1; Mammalian degenerin homolog; MDEG; modulatory subunit of ASIC2a; neuronal amiloride-sensitive cation channel 1; Neuronal amiloride-sensitive cation channel 3; proton gated cation channel ASIC1; proton gated cation channel DRASIC; proton-gated cation channel subunit; putative acid-sensing ion channel; spinal chord ASIC; Spinal cord ASIC; Testis sodium channel 1
基因别名: ACCN; ACCN1; ACCN2; ACCN3; ACCN4; ACIC2; AI843610; ASIC; ASIC1; ASIC1a; ASIC2; ASIC2a; ASIC3; ASIC4; AW742291; B530003N02Rik; BNAC1; BNaC1a; BNAC2; BNAC4; BNC1; BNC1k; DRASIC; hBNaC1; MDEG; MDEG1; MDEG2; SLNAC1; Spasic; TNAC1
UniProt ID:(Human) P78348, (Human) Q16515, (Human) Q9UHC3, (Human) Q6PIN9, (Mouse) Q6NXK8, (Rat) P55926, (Rat) Q62962, (Mouse) Q925H0, (Mouse) Q6X1Y6, (Rat) O35240, (Rat) Q9JHS6, (Mouse) Q7TNS7
Entrez Gene ID:(Human) 41, (Human) 40, (Human) 9311, (Human) 55515, (Mouse) 11419, (Rat) 79123, (Rat) 25364, (Mouse) 11418, (Mouse) 171209, (Rat) 286920, (Rat) 63882, (Mouse) 241118
参考图片
Expression of ASIC in rat PC12 cells - Cell surface detection of ASIC in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells with Anti-pan ASIC (extracellular) Antibody (#ASC-031), (1:25), followed by goat Anti-rabbit-AlexaFluor-488 secondary Antibody (green). B. Live view of the cells. C. Merge of A and B.
Expression of ASIC channels in rat locus coeruleus - Immunohistochemical staining of perfusion-fixed rat brain frozen sections using Anti-pan ASIC (extracellular) Antibody (#ASC-031), (1:400), followed by goat- Anti-rabbit-AlexaFluor-488. ASIC channel staining (green) appears in neuronal soma (arrows). Nuclei are stained with DAPI (blue).
Western blot analysis of mouse brain membranes (lanes 1 and 3) and human SH-SY5Y neuroblastoma cell line lysate (lanes 2 and 4): - 1-2. Anti-pan ASIC (extracellular) Antibody (#ASC-031), (1:500).3-4. Anti-pan ASIC (extracellular) Antibody , preincubated with Pan ASIC (extracellular) Blocking Peptide (#BLP-SC031).
Western blot analysis of rat dorsal root ganglion lysate (lanes 1 and 3) and rat brain membranes (lanes 2 and 4): - 1-2. Anti-pan ASIC (extracellular) Antibody (#ASC-031), (1:500).3-4. Anti-pan ASIC (extracellular) Antibody , preincubated with Pan ASIC (extracellular) Blocking Peptide (#BLP-SC031).