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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Parkin
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser65 of human Parkin protein. Antibodies are purified by peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
50
研究领域
神经科学
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
Phospho-Parkin (Ser65) Antibody recognizes transfected levels of Parkin protein only when phosphorylated at Ser65.
Species Reactivity:
Human
敏感性
Transfected Only
背景
背景
Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin (2).Parkin is phosphorylated by PINK1 at site Ser65. Phosphorylation at this site has been shown to be necessary for Parkin activation in vivo (3).
1.Tanner, C.M. and Goldman, S.M. (1996) Neurol. Clin. 14, 317-335.
2.Polymeropoulous, M.H. et al. (1997) Science 276, 2045-2047.
3.McWilliams, T.G. et al. (2018) Open Biol 8, 180108. doi: 10.1098/rsob.180108.
研究领域
神经科学
翻译后修饰
phosphate
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
5071
UniProt ID
O60260
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