PE Anti-DNA Polymerase beta antibody [EPR12722(B)]

Repair polymerase that plays a key role in base-excision repair (PubMed : 10556592, PubMed : 9207062, PubMed : 9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed : 10556592, PubMed : 17526740, PubMed : 9556598, PubMed : 9572863, PubMed : 9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed : 9614142).

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

PE兔单克隆抗体[EPR12722(B)] to DNA Polymerase beta

IgG

EPR12722(B)

单克隆

Protein A purified

Liquid

表观遗传学

Target Binding Affinity, Antibody Labelling

The human recommendation is based on the WB results. We do not guarantee IHC-P for human

DNA polymerase beta, 5'-deoxyribose-phosphate lyase, AP lyase, 5'-dRP lyase, POLB

pH: 7.40Preservative: 0.02% Sodium azideConstituents: 98% PBS, 1% BSA

P06746