PE Anti-Emerin antibody [EPR11071]

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed : 32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

PE兔单克隆抗体[EPR11071] to Emerin

IgG

EPR11071

单克隆

Protein A purified

Liquid

免疫学和肿瘤学

Antibody Labelling, Target Binding Affinity

EDMD, STA, EMD, Emerin

pH: 7.40Preservative: 0.02% Sodium azideConstituents: 98% PBS, 1% BSA

P50402