CD31 (PECAM-1) (89C2) Mouse mAb

CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3). 1.Newman, P.J. (1997) J. Clin. Invest. 99, 3-8. 2.Cao, M. Y. et al. (1998) J. Biol. Chem. 273, 15765-72. 3.Ilan, N. and Madri, J.A. (2003) Curr. Opin. Cell Biol. 15, 515-24.