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Peficitinib
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产品介绍
产品介绍
产品信息
抗原名称
JAK
商品描述
Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.
分子量
326.17
纯度
>98%
可溶性
DMSO : ≥ 60 mg/mL (183.83 mM)
外观
Powder
In vitro(体外研究)
ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5).
In vivo(体内研究)
In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score.
背景
别名
培菲替尼
分子式
C18H22N4O2
CAS号
944118-01-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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