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产品介绍
产品介绍
产品信息
抗原名称
aspartic protease
商品描述
Pepstatin is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
分子量
685.89
纯度
＞98%
可溶性
DMSO : ≥ 25 mg/mL
Ethanol : 1 mg/mL (1.46 mM)
Ethanol : 1 mg/mL (1.46 mM)
外观
white powder
In vitro(体外研究)
Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression.
In vivo(体内研究)
Pepstatin has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route. Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats.
背景
别名
胃酶抑素；胃蛋白酶抑制剂；胃酶抑素 A；抑肽素
分子式
C34H63N5O9
CAS号
26305-03-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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