全部商品分类
1/9
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Perilipin-1
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues around Ile419 of human perilipin-1 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
| Immunofluorescence (Frozen) | 1:100 - 1:400 |
| Immunofluorescence (Immunocytochemistry) | 1:100 - 1:400 |
同种型
Rabbit IgG
分子量
62
研究领域
癌症,代谢,神经科学
应用
反应种属
Human,Mouse,
目标/特异性
Specificity/Sensitivity
Perilipin-1 (D1D8) XP Rabbit mAb detects endogenous levels of total perilipin-1 protein.
Species Reactivity:
Human, Mouse
敏感性
Endogenous
背景
背景
Triacylglycerol is stored in lipid droplets as a primary energy reserve. Perilipin is localized at the periphery of lipid droplets and serves as a protective coating against lipases (1-3). Evidence suggests that PKA regulates lipolysis by phosphorylating perilipin (1,2,4,5). Phosphorylation of perilipin results in the conformational change that exposes lipid droplets to endogenous lipases, such as hormone-sensitive lipases (2). Hence, perilipin plays a pivotal role in lipid storage (2,5).
1.Greenberg, A.S. et al. (1991) J Biol Chem 266, 11341-6.
2.Brasaemle, D.L. (2007) J Lipid Res 48, 2547-59.
3.Ducharme, N.A. and Bickel, P.E. (2008) Endocrinology 149, 942-9.
4.Egan, J.J. et al. (1990) J Biol Chem 265, 18769-75.
5.Brasaemle, D.L. et al. (2009) Mol Cell Biochem 326, 15-21.
研究领域
癌症,代谢,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
For a carrier free (BSA and azide free) version of this product see product #57117.
数据库链接
Entrez-Gene ID
5346
UniProt ID
O60240
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。