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PF-04418948
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产品介绍
产品介绍
产品信息
抗原名称
EP₂ receptor
商品描述
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).
分子量
409.41
纯度
>98%
可溶性
DMSO : 130 mg/mL (317.53 mM; Need ultrasonic)
外观
white to beige powder
In vitro(体外研究)
PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea. PF-04418948 competitively inhibits relaxations of murine and guinea pig trachea induced by ONO-AE1-259 and PGE2 respectively. PF-04418948 restores neutrophil extracellular traps (NETs) formation in neutrophils isolated from BMT mice or HSCT patients.
In vivo(体内研究)
In Rats, PF-04418948 (10 mg/kg, p.o.) reduces the mean cutaneous blood flow peak response and AUC0–60 by 41% and 61%, respectively.
背景
别名
PF04418948；PF 04418948
分子式
C23H20FNO5
CAS号
1078166-57-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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