PFI 1 (10 mg)

71271629

BET bromodomain inhibitor

347.39

2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

Potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC₅₀ values are 98 and 220 nM respectively). Induces apoptosis and G₁ cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable.

≥98% (HPLC)

Soluble to 50 mM in DMSO

O=C2NC1=CC=C(NS(C3=CC=CC=C3OC)(=O)=O)C=C1CN2C

C₁₆H₁₇N₃O₄S

1403764-72-6