PFK 15 (10 mg)

25142799

Selective PFKFB3 inhibitor

260.29

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

Selective PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC₅₀ = 207 nM). Selective for PFKFB3 over a panel of 96 other kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits lung metastasis of Lewis lung carcinoma cell xenografts in mice.

≥99% (HPLC)

Soluble to 100 mM in DMSO

O=C(/C=C/C2=CC=C(C=CC=C3)C3=N2)C1=CC=NC=C1

C₁₇H₁₂N₂O

4382-63-2