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产品介绍
产品介绍
产品信息
抗原名称
PFKFB3
商品描述
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM.
分子量
260.29
纯度
>98%
可溶性
DMSO 19 mg/mL warmed (72.99 mM)
Ethanol 2 mg/mL warmed (7.68 mM)
Ethanol 2 mg/mL warmed (7.68 mM)
外观
Powder
In vitro(体外研究)
PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.
In vivo(体内研究)
In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
背景
别名
PFK015,PFK15,PFK 15,PFK-15
分子式
C17H12N2O
CAS号
4382-63-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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