PGC-1alpha (3G6) Rabbit mAb

PPARγ coactivator-1α (PGC-1α) was originally identified as a transcriptional coactivator whose expression closely correlated with adaptive thermogenesis following exposure to cold temperatures (1). Named for its association with the nuclear receptor peroxisome-proliferator activated receptor (PPARγ), PGC-1α interacts with a diverse array of transcription factors to regulate numerous aspects of cell physiology (2). PGC-1α helps to regulate cell processes important in adaptive thermogenesis and energy metabolism, including the related functions of glucose uptake, gluconeogenesis, insulin secretion, and mitochondrial biogenesis (3). Long thought to be a potential therapeutic target for the treatment of type II diabetes, obesity, cardiomyopathy, or other metabolic disorders (reviewed in 4), a recent functional survey found no obvious differences in PPARγ activity associated with recognized PGC-1α variants (5). 1.Puigserver, P. et al. (1998) Cell 92, 829-839. 2.Liang, H. and Ward, W.F. (2006) Adv. Physiol. Educ. 30, 145-151. 3.Tiraby, C. and Langin, D. (2005) Med. Sci. (Paris) 21, 49-54. 4.Finck, B.N. and Kelly, D.P. (2006) J. Clin. Invest. 116, 615-622. 5.Nitz, I. et al. (2007) Biochem. Biophys. Res. Commun. 353, 481-486.