Phospho-beta-Dystroglycan (Tyr892) (E6T9O) Rabbit mAb

Dystroglycan 1 (DAG1) is a ubiquitously expressed glycoprotein that is post-translationally processed into two protein subunits. α-dystroglycan is secreted and localizes to the outer plasma membrane, where it binds to the transmembrane subunit, β-dystroglycan. The two proteins form a complex that connects the cytoskeleton with the extracellular matrix and plays essential roles in various cellular processes, including neuromuscular junction function and adhesion-driven cell signaling (1,2).Phosphorylation of β-dystroglycan at Tyr892 regulates protein-protein interaction and subcellular localization (3-5). β-dystroglycan interacts with nuclear envelope proteins emerin and lamin B1 to regulate nuclear architecture and function (6). 1.Bozzi, M. et al. (2009) Matrix Biol 28, 179-87. 2.Moore, C.J. and Winder, S.J. (2012) Neuromuscul Disord 22, 959-65. 3.James, M. et al. (2000) J Cell Sci 113 (Pt 10), 1717-26. 4.Sotgia, F. et al. (2003) Biochemistry 42, 7110-23. 5.Gracida-Jiménez, V. et al. (2017) Sci Rep 7, 9906. 6.Vélez-Aguilera, G. et al. (2018) Biochim Biophys Acta Mol Cell Res 1865, 406-420.