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产品介绍
产品介绍
产品信息
抗原名称
ERβ
商品描述
PHTPP is an ERβ selective antagonist with 36-fold selective for ER βover ERα.
分子量
423.31
纯度
＞98%
可溶性
DMSO : 25 mg/mL (59.06 mM; Need ultrasonic)
外观
yellow to orange powder
In vitro(体外研究)
PHTPP is fully effective as an ERβ antagonist while exhibiting no significant agonism on ERα or Erβ. Treating cells with PHTPP reduces bladder cancer (BCa) cell growth and invasion, as well as MCM5 expression.
In vivo(体内研究)
PHTPP can inhibit bladder cancer growth and invasion, resulting in better survival rate in carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced BCa mouse model.
背景
别名
4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
分子式
C20H11F6N3O
CAS号
805239-56-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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