PI3 Kinase Class III (D9A5) Rabbit mAb

Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) (1). PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation (2,3). PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting (4). Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway (5). 1.Odorizzi, G. et al. (2000) Trends Biochem Sci 25, 229-35. 2.Panaretou, C. et al. (1997) J Biol Chem 272, 2477-85. 3.Kihara, A. et al. (2001) J Cell Biol 152, 519-30. 4.Corvera, S. (2001) Traffic 2, 859-66. 5.Yan, Y. and Backer, J.M. (2007) Biochem Soc Trans 35, 239-41.