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Presenilin 1 (D39D1) Rabbit mAb
品牌： CST
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对比
咨询分子量：
22 (CTF)
反应种属：
Human,Mouse,Rat,Monkey,
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Presenilin 1
来源纯化
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human Presenilin 1 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
同种型
Rabbit IgG
分子量
22 (CTF)
研究领域
神经科学
应用
反应种属
Human,Mouse,Rat,Monkey,
目标/特异性
Specificity/Sensitivity
Presenilin 1 (D39D1) Rabbit mAb recognizes endogenous levels of total Presenilin 1 protein. The antibody may detect a nonspecific band at 60 kDa.
Species Reactivity:
Human, Mouse, Rat, Monkey
敏感性
Endogenous
背景
背景
Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3).
1.Haass, C. and De Strooper, B. (1999) Science 286, 916-9.
2.Kimberly, W.T. et al. (2000) J. Biol. Chem. 275, 3173-3178.
3.Kim, T.W. et al. (1997) J. Biol. Chem. 272, 11006-11010.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
5663
UniProt ID
P49768
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