Anti-β1-Adrenergic Receptor (extracellular) Antibody

β-Adrenergic receptor (βAR) belongs to the superfamily of G protein-coupled receptors (GPCRs).  β-Adrenergic receptor (βAR) stimulation by the sympathetic nervous system or circulating catecholamines is involved in peripheral blood circulation, metabolic regulation, muscle contraction, and central neural activities.  In the heart, acute βAR stimulation serves as the most powerful means to regulate cardiac output in response to a fight-or-flight situation. There are three βAR subtypes, β1AR, β2AR and β3AR in cardiac myocytes¹. The receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, one extracellular N-terminal domain, and one intracellular C-terminal tail².
 
β1AR is the predominant receptor subtype expressed in human cardiomyocytes. β1AR is also expressed in the kidney³. It has been implicated in adipogenesis and memory formation⁴.
 
 β1AR has been widely connected with heart disease. Both the downregulation and overstimulation of β1AR have been connected to myocyte apoptosis. In addition chronic heart failure is characterized by abnormalities in β1AR signal transduction. It was demonstrated that heart failure is also inducible in animal models by overexpression of components of the β1AR signal transduction cascade. Transgenic mice overexpressing β1AR develop, with aging, heart failure similar to that observed in dilated cardiomyopathy in humans⁵.