Anti-BCMA bispecific antibody (DM16)

Purified from cell culture supernatant by affinity chromatography

Recombinant human BCMA (Met1-Ala54) produced by using human HEK293 cells

BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

DM16

Liquid; 0.1% Procline 300; 50% Glycerol; PBS, pH7.4; 0.1% BSA

Monoclonal

Flow Cytometry (FC/FACS), MM Tumor cell killing

Human

TNFRSF17

608