Anti-CD38 antibody (DM29), Rabbit mAb

Purified from cell culture supernatant by affinity chromatography

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Recombinant human CD38 (Val43-IIe300) produced by using human HEK293 cells

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

DM29

Liquid; 0.1% Procline 300; 50% Glycerol; PBS, pH7.4; 0.1% BSA

Monoclonal

ELISA (EIA), Flow Cytometry (FC/FACS)

Human

T10, cADPr hydrolase 1

952

P28907 [Other Products]