Anti-CD40 antibody (DM100), Rabbit mAb

Purified from cell culture supernatant by affinity chromatography

tumor necrosis factor receptor superfamily member 5 isoform 1

Recombinant human CD40 (Glu21-Arg193) produced by using human HEK293 cells

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

DM100

Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization. 0.1% Procline 300

Monoclonal

ELISA (EIA), Flow Cytometry (FC/FACS)

Human

CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50

958

P25942 [Other Products]