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Anti-CD40 antibody (DM100), Rabbit mAb

产品介绍
产品介绍
产品信息
纯化方式
Purified from cell culture supernatant by affinity chromatography

抗原名称
tumor necrosis factor receptor superfamily member 5 isoform 1

免疫原
Recombinant human CD40 (Glu21-Arg193) produced by using human HEK293 cells

商品描述
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

克隆号
DM100

形式
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization. 0.1% Procline 300

产品类型
Monoclonal

应用
实验应用
ELISA (EIA), Flow Cytometry (FC/FACS)

反应种属
Human

背景
别名
CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50

制备和贮存
保存方式
Store at -20 degree C for 12 months (Avoid repeated freezing and thawing)
数据库链接
NCBI
958

UniProt ID
P25942
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