Biotinylated Anti-41BB Ligand antibody (DM68), Rabbit mAb

Purified from cell culture supernatant by affinity chromatography

tumor necrosis factor ligand superfamily member 9

Recombinant human 4-1BB Ligand (Pro52-Glu254) produced by using human HEK293 cells

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

DM68

Liquid. 50% Glycerol; PBS, pH7.4; 0.1% BSA. 0.1% Procline 300

Monoclonal

ELISA (EIA), Flow Cytometry (FC/FACS)

Human

4-1BB Ligand; TNFSF9; CD137L

8744

P41273 [Other Products]