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Alpha-1-Antichymotrypsin Monoclonal Antibody
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产品介绍
产品介绍
产品信息
抗原名称
alpha-1-antichymotrypsin
商品描述
Alpha 1-antichymotrypsin (α1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. α1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. α1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils.
克隆号
1AC10-109.5
形式
Clear liquid; Protein G-purified antibody in PBS, pH 7.4
产品类型
Monoclonal
应用
实验应用
Immunoassay
背景
别名
Anti-Alpha-1-antichymotrypsin; Alpha-1- Anti-Chymotrypsin
制备和贮存
保存方式
These antibodies are stable for at least 1 year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
数据库链接
NCBI
12
UniProt ID
P01011
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