ATG3, CT (ATG3, APG3, APG3L, Ubiquitin-like-conjugating enzyme ATG3, Autophagy-related protein 3, Protein PC3-96)

Purified Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.

ATG3

ATG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90~120 amino acids from the C-term of human APG3L.

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Polyclonal

ELISA (EL/EIA), Western Blot (WB)

Human

Anti -ATG3, CT (ATG3, APG3, APG3L, Ubiquitin-like-conjugating enzyme ATG3, Autophagy-related protein 3, Protein PC3-96)