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RNF128, ID (RNF128, GRAIL, E3 ubiquitin-protein ligase RNF128, Gene related to anergy in lymphocytes protein, RING finger protein 128)
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产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by Protein A affinity chromatography.
免疫原
RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.
商品描述
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
形式
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
产品类型
Polyclonal
应用
实验应用
ELISA (EL/EIA), Western Blot (WB)
反应种属
Human
背景
别名
Anti -RNF128, ID (RNF128, GRAIL, E3 ubiquitin-protein ligase RNF128, Gene related to anergy in lymphocytes protein, RING finger protein 128)
制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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